Projetos e Parcerias

O CRER- CHULN/HSM colabora em várias atividades de investigação dentro da rede EPICARE

Estudos observacionais

  1. EPI 25 – Epi25 Collaborative for Large-Scale Whole Genome Sequencing in Epilepsy. Investigador principal – Dr.ª Sofia Quintas e Prof.ª Carla Bentes
  2. Inter-rater agreement on periodic and rhythmic EEG patterns using SCORE. Investigador principal – Prof.ª Carla Bentes
  3. Death in epilepsy (SUDEP) in a high-risk population: a development of a predictive model for sudden unexpected multicenter international retrospective case-control study” – Investigador principal – Prof.ª Carla Bentes
  4. Pinpoint project – n=1 trials for rare and complex epilepsies. Principal investigator – Dr.ª Sofia Quintas
  5. PROMAESIS – prospective multicentrer study on localization accuracy and clinical utility of automated electric source imaging in presurgical evaluation. Coordenador – Dr. Sándor Beniczky
  6. Interrater reliability of photoparoxysmal response – Coordenador – Dr. Sándor Beniczky

O CRER-CHULN/HSM também está envolvido em estudos científicos na área da epilepsia para além da rede EPICARE.

 

  1. EURAP – an international registry of antiepileptic drugs and pregnancy. Investigador principal Prof.ª Carla Bentes
  2. EpiEpiNET – epileptogenesis and epilepsy network – a network to foster research and training in epilepsy.
  3. Pre-Episeizures – Prediction of epileptic seizures based in the acquisition and processing of multimodal biosignals (em colaboração com o Instituto Superior Técnico). Investigador principal Prof.ª Carla Bentes
  4. Padrões de estado de mal e prognóstico. Tese Doutoramento. Lígia Ferreira. Orientador: Prof.ª Carla Bentes.

“Medição da variabilidade da frequência cardíaca e alternância da onda T em doentes com epilepsia submetido a estimulação do nervo vago”. Tese de Mestrado de Neurociências. Sofia Gago. Orientador: Prof.ª Carla Bentes.

PROMAESIS – Prospective multicentre study on localization accuracy and clinical utility of automated electric source imaging in presurgical evaluation”.
ERN-EpiCARE project. CRER-HSM Investigators: Bentes C.; Peralta R; Quintas S, Franco A. (2019-2026)

PINPOINT – Precision Treatments In MoNogenic EPilepsies: Observational registry and N-of-1 Trial. Retrospective registry study that will enable a comprehensive analysis of precision treatments for monogenic epilepsy syndromes in 28 European centers from the ERN-EpiCARE. CRER-HSM Investigator: Quintas S.
Sunflower syndrome. Targeted gene(s)/phenotype under study Sunflower syndrome research group. ENR EpiCARE Project. CRER-HSM Investigator: Quintas S.

EPI 25 Consortium. Genetic Basis of Epilepsy; Epi25 Collaborative for Large-Scale Whole Genome Sequencing in Epilepsy. CRER-HSM Investigators: Quintas S, Bentes C (2021- ongoing)

Projeto “Epilepsia de ausência infantil e juvenil: diagnóstico e prognóstico multimodal”. CRER-HSM Investigators: Quintas S, Bentes C

Projeto “Caracterização fenotípica e validação de um score de gravidade para crianças com encefalopatias epilépticas e do desenvolvimento”. Coordenado pelo Hospital San Juan Deu, Barcelona. CRER-HSM Investigator: Quintas S.

ExCeeD. Estudo de Expansão da Perturbação de Deficiência de CDKL5 do Hospital Infantil de Boston (caracterização de doentes com CDKL5 com fenótipo menos grave). CRER-HSM Investigator: Quintas S.

Estudo sobre Perturbação de Deficiência de CDKL5 (em modelo animal zebrafish), realizado pela Universidade do Algarve (Profª Leonor Cancela). CRER-HSM Investigator: Quintas S.

ELPIS (estudo liderado pela Ulysses Neuroscience, visa encontrar biomarcadores da Perturbação Défice CDKL5, como a alfa-tubulina acetilda e o BDNF). CRER-HSM Investigator: Quintas S.

LAMPSY (desenvolvimento de um aparelho para deteção de crises epilépticas incorporado num candeeiro), colaborando com Vicente Garção, aluno PhD do Instituto Superior Técnico. CRER-HSM Investigators: Bentes C, Quintas S. Peralta R, Franco A, Parreira S

European and International Registry of anti-epileptic Drugs and Pregnancy (EURAP)”. CRER-HSM Investigators: Bentes C, Franco A, Parreira S. (2015- ongoing)

SELECT Consortium. Research consortium dedicated to studying seizures and epilepsy after stroke. Principal Investigador: Marian Galovic. CRER-HSM Investigadors: Bentes C, Franco A (2019- ongoing)
Zanello M, Voges B, Chelvarajah R, Sen A, Petelin Gadže Ž, Penchet G, De Benedictis A, Fornaro R, Iwasaki M, Iijima K, Jiltsova E, Mrak G, Barrit S, Moiraghi A, Landi A, Neale M, Magdum S, Caire F, Godet B, Domenech P, Gaillard R, Guenot M, Labuschagne J, Rainha Campos A, Rooijakkers H, El Tahry R, Von Hertwig Fernandes De Oliveira T, Alvarez-Sala A, Torres CV, Vale F, Pallud J, Carron R. Right-sided vagus nerve stimulation: Worldwide collection and perspectives. Ann Clin Transl Neurol. 2025 Mar;12(3):565-576. doi: 10.1002/acn3.52312. Epub 2025 Feb 3. DOI: 10.1002/acn3.52312 1.2. Meyer GM, Pines AR, Roldan A, Aracil-Bolaños I, Settle EG, Sahin IA, Schaper FLWVJ, Neudorfer C, Järvenpää S, Kamo H, Piacentini SHMJ, Romito LM, Kim MJ, Goede LL, Butenko K, Bahners BH, Mosley PE, Rainha Campos A, Olaciregui Dague K, Boyd J, Widge AS, Dougherty DD, Temel Y, Rouhl RPW, Colon A, Kühn A, Maarouf M, Macerollo A, Farah JO, Oyama G, Hattori N, Lehtimäki K, Peltola J, Akram H, Foltynie T, Zhang C, Silbersweig D, Fox MD, Rolston JD, Aibar-Durán JA, Corripio I, Siddiqi SH, Horn A. Deep brain stimulation and psychosis: A case series and two candidate causal brain circuits. medRxiv [Preprint]. 2025 Nov 22:2025.11.18.25340443. doi: 10.1101/2025.11.18.25340443

Orphanet: Childhood absence epilepsy. Stephen Attardd, Eva Brilstra Gaetano Cantalupo, Sofia Quintas. https://www.orpha.net/en/disease/detail/64280 1.4. Matthias J. Koepp, Eugen Trinka, Mah Yee-Haur, Carla Bentes and al. Efficacy and safety of eslicarbazepine acetate for seizure prevention in stroke patients at high risk of developing post-stroke epilepsy: an exploratory, proof-of concept, phase-2a, randomised, double-blind, placebo-controlled antiepileptogenic trial. Acepted on December 26, 2025 Lancet Neurology. Lancet Neurol 2026 Mar;25(3):256-267. doi: 10.1016/S1474-4422(25)00491-0.